Cross Linking, Protein Modification & Protein Sample Preparation Handbook

Features cross linking applications and a valuable crosslinker selection guide


Cross linkingm protein modification and protein sample preparationCross linking of proteins, nucleic acids and biomolecules is a routine protein modification technique used in multiple applications, including:

  • Protein & Receptor Interactions
  • For Immunological Tools
  • Cell Membrane Structural Studies
  • Cell Surface Studies
  • Solid-Phase Immobilization
  • Preparation of Immunotoxins
  • Protein-Protein Conjugation
  • Protein to DNA/RNA Cross-Linking
  • Reactive Group Transfer

The Protein Crosslinkers Handbook gives an overview of the coupling chemistry of crosslinker reactive groups.  The included selection guide compares reactive groups, structures, spacer arm lengths, membrane permeability, water solubility and cleavability/reversability.

The Handbook features the following sections:

  • Introduction to Cross Linking Applications
  • Cross Lining Coupling Chemistry Overview
    • Primary Amine Reactive
    • Sulfhydryl Reactive
    • Carbohydrate Reactive
    • Carboxyl Reactive
    • Photoreactive
  • Selection Guide for Crosslinkers
    • Homobifunctional crosslinkers
    • Heterobifunctional crosslinkers
    • Photoreactive crosslinkers
  • Protein Reduction &Modification
  • Sample Preparation Accessories
    • Dialysis Systems
    • Desalting and Buffer Exchange

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